This paper aimed to unveil the diagnostic values of serum brain natriuretic peptide (BNP), pentraxin 3 (PTX3), and vascular endothelial growth factor (VEGF) in acute pulmonary embolism complicated by pulmonary artery hypertension (APE‐PAH) and their correlations with severity of PAH. The gene discussed is PTX3; the disease is apparent mineralocorticoid excess.