SARS‐CoV‐2 causes activation of several signaling pathways like nuclear factor κB (NF‐κB) and subsequently the release of pro‐inflammatory cytokines like pro‐IL‐1β which is then cleaved by caspase‐1, followed by inflammasome activation, leading to the production of active interleukin (IL)‐1β, a mediator of lung inflammation, fever and fibrosis14, 28, 29 (Figure 1). The gene discussed is IL1B; the disease is inflammation.