TFAM and Sepsis: Furthermore, previous in vivo and in vitro studies using sepsis models have demonstrated that sepsis damages the structure and function of mitochondria, leading to the overproduction of mitochondria‐derived danger‐associated molecular patterns (DAMPs) such as reactive oxygen species, fragmented mitochondrial DNA, N‐formyl peptides, cardiolipin, adenosine triphosphate, mitochondrial transcription factor A, and cytochrome c.44