The concentrations of IL‐1β (298.95 ± 4.72 pg/mL in the PPROM group and 149.43 ± 3.46 pg/mL in the PROM group) as well as IL‐18 (59.83 ± 0.46 pg/mL in the PPROM group and 46.76 ± 0.83 pg/mL in the PROM group) within the PPROM and control groups (IL‐1β: 85.31 ± 2.47 pg/mL and IL‐18: 38.72 ± 0.22 pg/mL) were notably lower compared with the TPROM group, and the difference was statistically significant (p < .05). This evidence concerns the gene IL18 and preterm premature rupture of the membranes.