An animal model of lipopolysaccharide‐induced intra‐amniotic inflammation (IAI) demonstrated that there was priming of the NLRP3 inflammasome at the transcriptional and expression, indicated by enhanced messenger RNA and protein expression of inflammasome‐related genes; and using the specific NLRP3 inhibitor, MCC950 can inhibiting of the NLRP3 inflammasome reduced IAI‐induced preterm birth and neonatal mortality.17 Here, NLRP3 is linked to inflammation.