Based on the results of the therapeutic efficacy study in vivo, we revealed for the first time that rAd‐FAP/hlivin α‐transduced DCs suppressed tumor volume and improved the survival of LLC mouse models, and these effects were more pronounced than those of rAd‐hlivin α‐transduced DCs or rAd‐FAP‐transduced DCs. This evidence concerns the gene FAP and neoplasm.