Further, Kaplan–Meier survival curves and log-rank test of these 20 types of cancers were assessed to identify that higher expression of BHLHE40 were correlated with worse prognosis in Glioblastoma multiforme (GBM), Acute Myeloid Leukemia (LAML), Brain Lower Grade Gliom (LGG), Ovarian serous cystadenocarcinoma (OV) and Pancreatic adenocarcinoma (PAAD) (Fig. 1B–F, Fig. S1A–O). Here, BHLHE40 is linked to cancer.