In contrast, BHLHE40 expression was not clearly related to survival of pancreatic cancer patients in subgroups such as Pathologic T stage: T1, T2 (Fig. S3A,B), Pathologic stage: Stage I (Fig. S3C), Primary therapy outcome: (PD, SD and PR and CR) (Fig. S3D,F), Gender: Female (Fig. S3E), Histologic grade: G3 and G4 (Fig. S3G), History of diabetes: No (Fig. S3H), Family history of cancer: Yes (Fig. S3I), Smoker: Yes (Fig. S3J), Radiation therapy: Yes (Fig. S3K). Here, BHLHE40 is linked to diabetes mellitus.