BHLHE40 and neoplasm: To investigate the expression of BHLHE40 in pan-cancer, we used TCGA and GTEX database including tumor tissues and normal tissues from 33 types of cancer to reveal that BHLHE40 were highly expressed in 7 of 33 tumor tissues compared to para-cancer tissues and were downregulated in 13 of 33 cancers (Fig. 1A).