BHLHE40 and familial pancreatic carcinoma: In parallel, univariate COX and multifactorial COX analyses including BHLHE40 revealed that BHLHE40 potentially serves as a prognostic predictor for patients with pancreatic cancer as a carcinogenic factor but is dependent on clinicopathological characteristics: pathological T and N, pathological stage, primary therapy outcome, and residual tumor (Table 1).