Regarding the pathway enrichment of BHLHE40-related genes, Kyoto encyclopedia of genes and genomes (KEGG) analysis displayed that the PI3K-AKT, Toll-like receptor, Wnt signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Th17 cell differentiation was remarkably enriched (Fig. 5G). This evidence concerns the gene AKT1 and cancer.