And Plasmacytoid Dendritic Cells (pDC) (R =  − 0.277), Follicular helper T cell (TFH) (R =  − 0.314), Tgd (R =  − 0.243), Cytotoxic cells (R =  − 0.184, P = 0.014), B cells (R =  − 0.17, P = 0.023) and Th17 cells (R =  − 0.21, P = 0.005) from pancreatic cancer patients (Fig. 6D–I) were negatively correlated to BHLHE40. The gene discussed is BHLHE40; the disease is familial pancreatic carcinoma.