LEP and obesity due to melanocortin 4 receptor deficiency: Although we observed elevated levels of peripheral inflammatory markers typical of obesity, such as leptin, and INF-ɣ, in the hippocampus we did not observe damage to the integrity of the BBB or neuroinflammatory features associated with exposure to an obesogenic diet, which overturned our hypothesis that increased glutamate levels in the hippocampus could be associated with hippocampal neuroinflammatory mechanisms triggered by obesogenic peripheral inflammation (Figs. 2, 3, 4, 5 and 6).