Although none of these studies evaluated whether decrease in synaptic plasticity and memory were associated with glutamatergic neurotransmission, it has been demonstrated that HFD promotes a downregulation of NMDA hippocampal NR2B subunit, which may lead to dysfunctions in synaptic plasticity dependent on LTD, likely contributing to plastic decline regulation in an obesity environment34. This evidence concerns the gene GRIN2B and obesity disorder.