The most common rearrangements in NSCLC result from an inter-chromosomal inversion in the short arm of chromosome 2, which creates a fusion between the 5’ portion of the EML4 gene and the 3’ portions of the ALK gene Inv (2) (p21p23) (Fig. 1b)3,20,23–25. The gene discussed is EML4; the disease is non-small cell lung carcinoma.