Desai and colleagues analyzed 11,107 tumor samples from 10,082 patients of lung adenocarcinoma from AACR Genie data base91 and found 584 (5%) samples with ALK gene alterations: 354 missense mutations (60.6%); 265 cases with fusions (45.4%); 51 with truncating mutations (8.7%); and 1 case with in-frame mutation (0.17%). This evidence concerns the gene ALK and neoplasm.