We are the first to establish a relationship between YAP1 and ferroptosis in CRPC and clarify that YAP1 can inhibit ferroptosis by improving the antioxidant capacity of CRPC cells, which is different from the relationship between YAP1 and ferroptosis in colorectal cancer from the perspective of oxidation [33, 37, 38]. The gene discussed is YAP1; the disease is colorectal cancer.