CD8+ T cells derived from the spleens of non-TB mice mock-vaccinated with PBS were mainly localized in naïve clusters (58%), whereas CD8+ T cells derived from the spleens of non-TB mice vaccinated with HPV mRNA-LNPs had a lower frequency in naïve clusters (27%); they were mainly localized in the IFN-induced clusters (22%), indicating the rapid initiation of innate immune responses22,23. This evidence concerns the gene CD8A and tuberculosis.