TNF and neoplasm: First but not foremost, an Anti-tumor effect was observed in Lactobacillus bulgaricus, of which the administration inhibited mean tumor size and total tumor volume in azoxymethane (AOM)/ DSS-induced CAC mouse model with remarkably reduced pro-inflammatory cytokines containing IL-6, TNF-α, IL-1β, IL-17, and IL-23 [92].