Moreover, serum interferon (IFN)-β, IL-6, and IL-10 were highly correlated with the occurrence of acute/subacute interstitial pneumonia (A/SIP) in PM/DM [14], and elevated IL-8 levels along with lower ratios of IL-4 to IFN-γ may contribute to the occurrence of anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5)-positive PM/DM-ILD [13]. This evidence concerns the gene IFIH1 and interstitial lung disease.