Taken together, these data revealed that METTL16, ALKBH5, YTHDF2/YTHDC1 were involved in m6A install, remove and recognize of TIALD, respectively, while m6A-modification decrease the stability of TIALD, thus leading to downregulation of TIALD expression in HCC. This evidence concerns the gene METTL16 and hepatocellular carcinoma.