METTL16 and hepatocellular carcinoma: In summary, our study revealed that lncRNA TIALD acted as a tumor suppressor which was down-regulated via METTL16 mediated m6A methylation, and contributed to HCC metastasis via inducing degradation of AURKA, and AURKA inhibitor alisertib exhibited significant effect of inhibiting metastasis in TIALD knockdown HCC.