The observation that sHVF18 was able to target multiple sepsis-related genes, such as LCN2, TNIP1, NFkB1 & 2, SNX10, TNFAIP3, MMP14, BCL3, SERPINE1, SOD2, IL6RA, and ICAM1, prompted us to use a more complex in vivo model, i.e., the cecal ligation and puncture (CLP) model of sepsis (Supplementary Fig. 23a). The gene discussed is IL6R; the disease is Sepsis.