While low leptin levels and functional hypercortisolism are known to underlie hypothalamic amenorrhea in undernourished patients with AN, and the administration of recombinant leptin has been shown to restore menses in women with hypothalamic amenorrhea and leptin deficiency [27, 28] the normalization of these hormones post-weight recovery implies that they might not be directly associated with the ongoing amenorrhea in this context. Here, LEP is linked to adrenal gland hyperfunction.