BBC3 and neoplasm: Consistent with the oncogenic role of AKT, FOXO target genes include tumor-suppressive genes (BCL2L11(Bim), BBC3(PUMA), CDKN1B(p27Kip)), and overexpression of FOXOs induces apoptosis and cell cycle arrest, while suppression of FOXOs promotes tumorigenesis in prostate, gastric, and thymic tumors [4–9].