Accordingly, HFD-fed Tmem135TG mice exhibited a marked improvement in glucose tolerance (Fig. 5j and Supplementary Fig. 5i) in the context of hypoinsulinemia (Fig. 5k) and increased circulating adiponectin levels (Supplementary Fig. 5j), suggesting that TMEM135 promotes insulin sensitivity. Here, TMEM135 is linked to Hypoinsulinemia.