TMEM135 and type 2 diabetes mellitus: Moreover, analysis of AMP-T2D-GENES exome sequencing data of samples from Starr County, Texas48 led to the identification of a coding variant of TMEM135 (dbSNP: rs549195058) that results in a glycine to glutamic acid replacement at position 369 (G369E) in transcript variant 1 (G347E in transcript variant 2) and is associated with increased BMI specifically in a sub-cohort representing 13,000 Hispanic samples (Fig. 7g).