Suggesting that TMEM135 might be relevant to obesity in humans, analysis of publicly available transcriptome-profiling data (GEO: GSE94753) indicates that Tmem135 gene expression is significantly decreased in abdominal subcutaneous WAT of female subjects with obesity as compared to lean individuals (Fig. 7f). This evidence concerns the gene TMEM135 and obesity due to melanocortin 4 receptor deficiency.