Although some studies have linked CA125, CA15-3, CA19-9, CA72-4, and CYFRA21-1 to lung adenocarcinoma metastasis [24], no studies have confirmed that CA125 can be used as a prognostic marker, and only a small number of studies have discussed its prognostic value in advanced cancer [25], other studies have shown that NSE is an important prognostic factor for advanced locally metastatic NSCLC [18, 26]. Here, ENO2 is linked to lung adenocarcinoma.