After adjusting for age, BMI, WHR, T2DM course, HbA1c, blood pressure, smoking and drinking rate, blood lipid and EGFR, the OR (95% CI) of DPN in the last quartile was 1.956 (1.371, 2.792) and that in the third quartile was 1.854 (1.319, 2.608). The gene discussed is EGFR; the disease is type 2 diabetes mellitus.