NRAS and melanoma: Moreover, Gong et al. showed that similar to BRAF and NRAS mutations, the frequency of c-KIT mutation in melanoma is influenced by the anatomical site of the primary tumor: genitalia and extremities having the highest mutation rate (of 26 to 35%), anorectal melanoma expresses in 35% of cases cKIT mutations, while in sinonasal tract cKIT mutations are observed in 22% of MM [37].