As mentioned above, cKIT mutations distinguish the subtype of triple-negative melanoma, often associated with the activation of splicing factor 3b subunit 1 (SF3B1), a protein involved in RNA splicing and transcriptomic regulation (with a higher trend of R625C and R625H mutations in vulvovaginal and anal or rectal melanomas) [36] and Telomerase Reverse Transcriptase (TERT) promoter mutations. This evidence concerns the gene SF3B1 and rectum malignant melanoma.