TP53 and cancer: Interestingly, when analyzed by PCA based on the pathway enrichment scores, the Hippo pathway signature was more strongly associated with the basal-like subtypes of cell lines and tumors than other major cancer-associated pathways including p53, PI-3K, or Ras pathways (Supplementary Fig. 14, right panels), as indicated by the higher Calinski-Harabasz (CH) Indices of the Hippo pathway, which measured the strength of clustering of the basal-like sample group relative to other subtypes.