The p53 protein controls multiple cellular programs that suppress cancer and is activated by various stimuli which then mediate tumor suppression by transient cell-cycle arrest, induction of senescence, apoptosis and DNA-repair, called the canonical p53 functions7,8 and also, regulate cell metabolism, stem cell maintenance, invasion and metastasis prevention, called the non-canonical functions9. The gene discussed is TP53; the disease is neoplasm.