Compared to breast cancer cell lines with multiple oncogenic mutations that have been used to study cellular impacts of TP53 mutations, the isogenic MCF10A cell line model used in this study is highly informative in measuring the p53 missense mutation-specific changes without confounding interference from other genetic and epigenetic alternations, although we fully acknowledge that single cell line models have clear limitations in understanding the full spectrum of functional impacts of TP53 mutations in the context of highly heterogenous TNBC. The gene discussed is TP53; the disease is breast carcinoma.