Importantly, the heterogeneous phenotypic changes induced by the ten different p53 mutants in this study correlated well with overall survival of the basal-like breast cancer patients (Fig. 3b, c, and Supplementary Fig. 10), which supports the clinical relevance of our MCF10A model system for studying cellular and molecular mechanisms of the phenotypic heterogeneity. This evidence concerns the gene TP53 and breast cancer.