Recently, however, two studies have reported RV-C15 – a prevalent strain in humans that may cause severe symptoms – infection of C57BL/6J mice induced the upregulation of remodeling-associated genes MUC5AC and MUC5B, elevated IL-25, IL-33, and TSLP levels, and increased numbers of lung ILC2s [94, 190]. Here, MUC5AC is linked to infection.