These findings highlight the importance of counteracting MARCH1 during primate lentivirus infection of myeloid cells and underline the potential role of miRNA-25/miRNA-93 in this counteraction, although the mechanism driving miRNA-25/miRNA-93 upregulation during HIV-2 or SIVmac infection is likely to be different than in the case of HIV-1. Here, MARCHF1 is linked to infection.