As shown in Table 3, increasing copy number of Fn is associated with a higher probability of colorectal cancer with MLH1 hypermethylation (OR: 1.56, P < 0.0001), MSI-H (OR: 1.5, P < 0.0001), and BRAFV600E (OR: 1.33, P = 0.027), but not with KRAS mutations (OR: 1.15, P = 0.113) in univariate logistic regression analysis. This evidence concerns the gene MLH1 and colorectal cancer.