Here, MSI-H-CRC, MLH1 hypermutated-CRC, BRAFV600E-CRC and KRAS mutated-CRC had higher Fn loads compared with non-MSI-H-CRC (P < 0.0001), non-MLH1 hypermutated-CRC (P = 0.001), non-BRAFV600E-CRC (P = 0.022) and non-KRAS mutated-CRC (P = 0.037), respectively (Fig. 1A). Here, MLH1 is linked to colorectal carcinoma.