The minimum amounts of Fn DNA detected in our colorectal cancer cohort were 0.02 pg (equivalent to one copy of Fn genome) per one nanogram of tumor DNA and the maximum amounts were 291 pg (equivalent to 124,467 copies of Fn) per one nanogram of tumor DNA, respectively (Supplementary Fig. S2; Supplementary Table S1). This evidence concerns the gene FN1 and neoplasm.