BRAF and colorectal carcinoma: Note that Fn colonizes less efficiently in KRAS mutated-CRC compared with MLH1 hypermethylated-CRC or MSI-H-CRC; however, it colonizes more efficiently in KRAS mutated-CRC compared with non-KRAS mutated-CRC (Fig. 1A).We further examined the relationship between each genotype including MSI-H, MLH1 hypermethylation, BRAF mutations, and KRAS mutations (response variables) and copy number of Fn (explanatory variable) using logistic regression analysis.