We previously reported that Fn directly caused DNA damage in infected tissues and its infection was enriched in two subgroups of colorectal cancers, one exhibiting MSI-H and another exhibiting low levels of microsatellite instability (MSI-L) and elevated microsatellite alterations in selected tetranucleotide repeats (EMAST; L/E; ref. 10). This evidence concerns the gene FN1 and colorectal cancer.