MLH1 and neoplasm: After adjusting for tumor site and stage, and patients’ age, sex, and race, a higher copy number of Fn is independently associated with MLH1 hypermethylation (OR: 1.46, P < 0.0001), MSI-H (OR: 1.5, P < 0.0001), slightly with BRAFV600E (OR: 1.21, P = 0.051) but not with KRAS mutations (OR: 1.15, P = 0.142; Table 3).