IL18 and leukemia: Next, we stimulated parenteral [wild-type (WT)] and NLRP3-deficient (NLRP3−/−) human leukemia monocytic (THP-1) cells with CM obtained from Panc-1 cells, as for Fig. 2A, to investigate a possible role of NLRP3 in the production of IL1β and IL18 in myeloid cells.