Together with our findings that treatment of latently HCMV infected CD34+ HPCs at the time of reactivation with DKK1 decreases the ability of the virus to reactivate in vitro (Fig. 2D), this suggests a conserved role of the Wnt pathway in CMV infection that is different from α- and γ-herpesvirus. The gene discussed is DKK1; the disease is cytomegalovirus infection.