Emerging reports now describe other phenotypes associated with FUS variants including learning and intellectual impairments sometimes coincidental with ALS (Yamashita et al., 2012; Lanteri et al., 2021), and such deficits can be shown by structural alterations in magnetic resonance imaging (MRI) brain scans (Hirayanagi et al., 2016). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.