In another whole-genome DNA methylation study, six genes (APIS3, C16orf59, KCNK15, LOC146336, MGC16384, and XRN2) were found to be hypermethylated and were identified as good markers of treatment-induced effects in male schizophrenia patients before and after achieving complete remission (Rukova et al., 2014). Here, XRN2 is linked to schizophrenia.