PCYT2 and metabolic dysfunction-associated steatohepatitis: These questions are particularly perplexing, given that mice heterozygous for Pcyt2 global ablation develop nonalcoholic steatohepatitis,5 while liver-specific deletion of this enzyme causes hepatosteatosis without liver injury or impaired hepatic insulin signaling,9 necessarily implicating extra-hepatic organ systems in the pathology.