Among 14 families diagnosed with MPS, 6 novel and 6 reported variants were identified, where 11 families carried variants in MPS-associated genes (NAGLU, SGSH, GALNS), two families carried variants in two genes (VWA3B, GNPTG) that were not previously associated with MPS phenotypes, while one family remained genetically undiagnosed. The gene discussed is VWA3B; the disease is mucopolysaccharidosis.