Considering the expression status of these seven genes, we found that GES7high tumors are characterized by the activation of the transforming growth factor beta (TGF-β), an essential fibrogenic agent that can promote an invasive phenotype, immunosuppression, and an interplay between tumor and stromal cells (Balkwill et al., 2012; Colak and ten Dijke, 2017; Henke et al., 2020). The gene discussed is TGFB1; the disease is neoplasm.