A marker for the prediction of metastasis, E-cadherin methylation and catenin degradation may be new targets for OSCC invasion and metastasis suppression. It has been correlated with tumor differentiation, invasion, metastasis, and prognosis [10]. One of the biggest challenges faced by healthcare professionals treating oral diseases is predicting which potentially malignant mucosal diseases (PMD), such as oral erythroplakias, leukoplakias, and lichenoid, will progress to neoplasia, specifically OSCC [11]. The gene discussed is CDH1; the disease is Pelizeaus-Merzbacher spectrum disorder.