Interestingly, the focus on GlialCAM as a target in MS occurred due to the remarkable molecular mimicry of this protein with EBV nuclear antigen 1 (EBNA1), which is a peptide derived from the Epstein–Barr virus (EBV) and thought to be necessary, but not sufficient, to cause MS (Aloisi et al., 2023). Here, HEPACAM is linked to myeloid sarcoma.