Hence, it is highly likely that a phenomenon of epitope spreading (i.e., when an immune response spreads to other epitopes that are close to the initial target) is occurring with GlialCAM and surrounding transmembrane proteins, and could be part of the oligoclonal IgGs found in MS CSF (Lanz et al., 2023). The gene discussed is HEPACAM; the disease is myeloid sarcoma.