CD274 and acute respiratory distress syndrome: To confirm the impact of sPD-L1 intervention on the survival period of ARDS-modeled mice, we monitored the effect of a single dose of PD-L1-Fc (0.8 mg/kg), sPD-L1 mRNA-MC3-LNPs (0.2 mg/kg), and sPD-L1 mRNA-DOTAP-LNPs (0.2 mg/kg) on the 7-day survival rates of the ARDS mice (Figure 6L).