In this study, we identified novel and important functions of Trx-1 nuclear translocation in various aspects of CRC progression; specifically, we demonstrated that nuclear translocation of Trx-1 promotes EMT and metastasis of CRC by enhancing IL-6/STAT3 signaling through interaction with STAT3 in vitro and in vivo. The gene discussed is TXN; the disease is colorectal carcinoma.