This study further determined that IL-6-induced Trx-1 nuclear translocation plays critical roles in EMT, invasion and metastasis of CRC cells, and progression of CAC through an interaction of Trx-1 with STAT3, with karyopherin α1 specifically strengthening the Trx-1-STAT3 complex to accelerate its nuclear translocation. The gene discussed is STAT3; the disease is colorectal carcinoma.