The blood glucose (db/m: 24.23 ± 1.071 mmol/L, db/db: 6.61 ± 0.37 mmol/L), body weight (db/m: 52.8 ± 1.09 g, db/db: 33.47 ± 0.77 g), kidney weight (db/m: 0.215 ± 0.005 g, db/db: 0.181 ± 0.006 g) and albumin-to-creatinine ratio (ACR, db/m: 554.80 ± 73.51 μg/mg·Cr, db/db: 58.38 ± 19.06 μg/mg·Cr) of 15 W db/db mice were significantly higher than those of db/m mice (Figure S7), consistent with previous studies 48, confirming that the 15 W db/db mice showed obvious symptoms of diabetes. Here, ALB is linked to diabetes mellitus.