Immune cells with high or low Tim-3 expression were intravenously injected into 4T1 tumor-bearing mice, the results showed that the injection of Tim-3+cDC2 exhibited an impaired ability to initiate the production of IFN-γ in CD4+ T cells compared with the injection of Tim-3-cDC2. This evidence concerns the gene HAVCR2 and neoplasm.