For example, CD8+ T cells pretreated with PD-1 Nb20 and DC/tumor cell fusion cell vaccines significantly inhibited the growth of NSCLC, HCC, and TSCC xenografts, enhanced T cell infiltration into the tumor tissues and inhibited tumor angiogenesis, which provided an alternative immunotherapy strategy for tumor patients with or without T cell dysfunction 35. The gene discussed is CD8A; the disease is hepatocellular carcinoma.