Numerous studies revealed that TRIM proteins play various roles in cell biology, including in innate immunity or anti-tumor immune response 5, 6, oncogenic or anti-oncogenic development 7, chromatin modification 8, pyroptosis 9 and self-renewal in cancer stem cells 10, via controlling gene transcription, post-translational modifications, and interaction with pathogens. The gene discussed is TRAT1; the disease is neoplasm.