TRIM21 and glioblastoma: As anticipated, TRIM21 markedly increased in Grade IV GBM material in comparison with Grade III (P < 0.05), Grade II (P < 0.05), Grade I (P < 0.01) or Normal brain samples (P < 0.05; Figure 1E-F and Table 1), which was also observed in TCGA database (Figure S1D).