Depending on the cancer type and the carcinogenesis effector, TRIM21 may change cancer progression, alternatively through increasing the ubiquitination of oncogenic or tumor suppressor proteins 15.We also discover that TRIM21 not only promotes K63-linked ubiquitination of β‐catenin, accelerating its translocation into nuclei, but also increases β‐catenin in nucleus by enhancing K48-linked ubiquitination of TIF1γ, another important regulator of β‐catenin 14, 16, thereby resulting in high transcriptional activity of Wnt/β‐catenin in GBM cells. This evidence concerns the gene TRIM21 and cancer.