Continually, Jia and co-workers found that MLN4924-induced neddylation inhibition caused the accumulation of ATF3 to promote prosurvival autophagy by regulating NF-κB-Catalase-ROSATF3 axis in esophageal cancer cells, suggesting inhibition of ATF3-mediated autophagy as a promising strategy to improve neddylation mediated ESCC treatment 120. Here, ATF3 is linked to esophageal squamous cell carcinoma.