It was reported that the effect of SCE on attenuating fibrosis was closely linked with the downregulation of TGF-β/Smad3 signaling and that SCE can inhibit the increase in the levels of H3K4me3 and H3k36me3 in the Smad3 promoter region induced by TGF-β in CFs (Figure 3) (Yang et al., 2019). This evidence concerns the gene SMAD3 and myalgic encephalomeyelitis/chronic fatigue syndrome.