NFE2L2 and neoplasm: SIRT1: Silencing regulatory protein 1; Nrf2: encoded by the NFE2L2 gene, regulating approximately 250 genes involving in cellular homeostasis; H9C2 cells: Embryonic rat cardiomyocytes; uPA: a multifunctional serine protease with a relative molecular weight of 55,000 kDa, which can be synthesized by fibroblasts, monocyte, neutrophils, epithelial cells, and tumor cells; SP1: sequence-specific DNA binding proteins that regulates the transcription of cellular and viral genes rich in GC sequences in certain promoters.