High levels of lipids in skeletal muscle can lead to insulin resistance (Al Saedi et al., 2022) and influence muscle mass by reducing the phosphorylation of protein kinase B (Akt) (Bailey et al., 2006), which is closely related to postmenopausal osteoporosis and sarcopenia (Wei et al., 2021). Here, AKT1 is linked to postmenopausal osteoporosis.