The results showed that, while gut microbiota of patients with MNS had reduced expression of MYHCIIA (pTWN VS CG =0.0194, Figure 1G) in the muscle of mice, the effect on MYHCIIB was not significant (pTWN VS CG =0.1436, Figure 1H). Here, MYH4 is linked to Melnick-Needles syndrome.