The impact of IFN-γ on remodeling is reflected in its prominent antiproliferative and antifibrotic effects (35) and IFN-γ has been found to reduce fibrosis in liver (36) and kidney (37) fibrosis models by inhibiting TGF-β activity, or can also inhibit fibroblast activation and proliferation to exert anti-fibrotic effects (37) and suppress collagen synthesis (38). This evidence concerns the gene IFNG and fibrosis.