FGF can promote fibrosis when it is involved in CRS remodeling by transforming the epithelial cells into fibroblast-like cells (86), whereas it was discovered that significantly more basic FGF-2 was found in the nasal secretions of CRS patients (87), which can attract leukocytes to secrete the different inflammatory mediators in acute and chronic inflammatory conditions (88). Here, FGF2 is linked to congenital rubella syndrome.