IL22 and congenital rubella syndrome: Moreover, based on the transcription factors and the cytokines produced, ILCs have been divided into three subtypes, ILC1s, ILC2s, and ILC3s (151), and these three cell subtypes produce high levels of the similar cytokines as TH cells, such as ILC1 secretes IFN-γ, ILC2 produces IL-5 and IL-13, and ILC3 secretes IL-17 as well as IL-22 (152), and thus play an important role in the pathogenesis of CRS.