The immunosuppression feature has been recognized as a general hallmark of PDAC TME, characterized by heightened infiltration of tumor-promoting myeloid cells including tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), myeloid-derived suppressor cells (MDSCs), and mast cells, along with impaired number and function of anti-tumor immune cells such as CD8 T cells, Dendritic cells (DCs), and natural killer cells (NKs) (4, 5). The gene discussed is CD8A; the disease is neoplasm.