Furthermore, T cells from SLE patients exhibit abnormal microRNAs (for example, miR-200a-3p) and enzymatic activity of protein phosphatase 2A (PP2A), resulting in downregulation of IL-2 by inactivation of the phosphorylated cAMP response element-binding protein (pCREB) (16, 70). Here, IL2 is linked to systemic lupus erythematosus.