In most tumors, ADAR1 plays a role in promoting cancer development, and increased ADAR1 expression is associated with the persistent development of many cancers such as triple-negative breast cancer, thyroid cancer, glioblastoma, ovarian cancer, esophageal squamous cell carcinoma, gastric cancer, pancreatic cancer, and endometrial cancer (92–99). Here, ADAR is linked to esophageal squamous cell carcinoma.