ZBP1 and infection: Following infection with IAV, the NLRP3 of the host activates, and then a large number of pro-inflammatory cytokines secretes, while in the Ripk3-/- Casp8-/- Ripk1-/- and Zbp1-/- bone marrow-derived macrophages (BMDMs), pro-inflammatory cytokines are no longer secreted (74, 75).