CCL2 and cancer: Moreover, several chemokines that are known to play a prominent role in metastasis of cancer cells, namely, CCL2, CCL5, CCL7, CCL20, CXCL1, CXCL3, CXCL5, and CXCL11 were upregulated in CT26 after treatment with CX3CL1 (Figure 5A).