Our results show that this axis generates a pro-tumorigenic and immunosuppressive program as MAPK38, PARP, NLRP3, MMP3/9/10/13, NF-kB, IL-1 are upregulated and multiple soluble mediators including G-CSF, CCL2, CCL5 (alias; RANTES), CXCL7, CCL20 (alias; macrophage inflammatory protein-3; MIP-3α), CXCL1, CXCL3, CXCL5, CXCL11, IL-6, LIF (member of the IL-6 family) are secreted when CX3CR1 positive CT26 tumor cells are treated with CX3CL1 recombinant protein. Here, CX3CR1 is linked to neoplasm.