CX3CL1 and neoplasm: In summary, our results show that the CX3CL1-CX3CR1 axis can promote tumorigenesis and immune-suppression by 1) Signaling through CX3CR1 that recruits myeloid populations and enhances secretion of soluble mediators by the tumor; 2) Increase of NLRP3 inflammasome component in the tumor; 3) Increase of pro-tumorigenic programs in the tumor.