To investigate whether the γ-adducin 1–357 fragment regulates tau phosphorylation in AD, we co-transfected HA-tau 1–441 together with GST-vector, GST-γ-adducin, or GST-γ-adducin 1–357 fragment into HEK293 and SH-SY5Y cells. Here, MAPT is linked to Alzheimer disease.