PubMed was searched for articles written in the English language and published between Jan 1, 1970, and April 1, 2023 using the search terms “ceroid,” “lipofuscin” “Batten,” “juvenile NCL,” “NCL,” “CLN3,” “neurodegeneration”; “Parkinson’s disease”; “dementia”; “Alzheimer”; “anxiety”; “fear”; “autonomic dysfunction”; “dysautonomia”; “paroxysmal sympathetic hyperactivity”; “sympathetic nervous system”; “parasympathetic nervous system”; “heart rate variability”; “vagal stimulation”; “heart and brain.” The final reference list was generated on the basis of relevance to the topic covered. The gene discussed is CLN3; the disease is Anxiety.