identified a critical role for SLFN5 in maintaining non-/low-invasive cancer cell lines (breast cancer cell line MCF5, colorectal cancer cell line HCT7, and lung cancer cell line A116) in a non-invasive state, and found that the β-cartenin pathway mediated SLFN5 on MT1-MMP expression (17). Here, SLFN5 is linked to cancer.