However, it cannot be ignored that there are still a large number of problems to be solved in the study of SLFN5, such as the lack of research on the regulatory mechanism and effect of SLFN5 in gastric cancer and glioblastoma, and the lack of research on the effect of SLFN5 as a biomarker of chemotherapy and a potential target of antitumor drugs in the clinic, on the one hand, it is because the effect of SLFN5 is not universal, and has not the same effect on different types/subtypes of cancers, on the other hand, it is not universal. Here, SLFN5 is linked to glioblastoma.